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Capture more cfDNA & cfRNA
to let Cancer Early Detection become possible




Circulating Cell-Free DNA (cfDNA)

Cell-free DNA (cfDNA) has emerged as a powerful biomarker for ​non-invasive diagnostics, especially in Cancer detection, Prenatal screening, and Organ transplant monitoring. Since its discovery, cfDNA has been extensively studied for its potential applications in liquid biopsies, allowing real-time monitoring of disease progression and treatment responses. This article provides an overview of the history of cfDNA discovery, its applications in medicine, and the methods used for cfDNA purification.
The Discovery of Cell-Free DNA

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cfDNA was first discovered in 1948 by Mandel and Metais, who identified the presence of nucleic acids in human plasma. However, it was not until the 1990s that cfDNA research gained significant momentum, particularly when scientists observed elevated levels of circulating tumor DNA (ctDNA) in cancer patients. This discovery laid the foundation for the use of cfDNA as a biomarker for cancer detection and disease monitoring. The role of cfDNA became even more prominent in 1997, when Dennis Lo and his colleagues demonstrated the presence of fetal cfDNA in maternal blood, paving the way for non-invasive prenatal testing (NIPT). Over the past two decades, technological advancements in next-generation sequencing (NGS) and polymerase chain reaction (PCR) have made cfDNA analysis an essential tool in medical diagnostics.
Applications of cfDNA

cfDNA has revolutionized several fields of medicine, with its applications spanning cancer detection, prenatal screening, organ transplant monitoring, and inflammatory disease diagnostics.
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1. Cancer Detection and Liquid Biopsies

One of the most significant applications of cfDNA is in cancer detection through liquid biopsies. Tumors shed circulating tumor DNA      (ctDNA) into the bloodstream, which can be analyzed for tumor-specific mutations, epigenetic changes, and copy number variations.

2. Prenatal Screening
cfDNA has transformed non-invasive prenatal testing (NIPT). Fetal cfDNA can be detected in maternal blood as early as 10 weeks of gestation, allowing for screening of chromosomal abnormalities such as:
  • Down syndrome (Trisomy 21)
  • Edwards syndrome (Trisomy 18)
  • Patau syndrome (Trisomy 13)
This advancement eliminates the risks associated with amniocentesis and chorionic villus sampling (CVS), making prenatal screening safer for both mother and child.

3. Organ Transplant Monitoring
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cfDNA is now used to monitor organ transplant rejection by detecting donor-derived cfDNA (dd-cfDNA) in the recipient’s blood. Increased levels of dd-cfDNA indicate organ damage, allowing for early intervention before full rejection occurs.

4. Inflammatory Diseases and Autoimmune Disorders
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Recent research suggests that cfDNA could be a biomarker for inflammatory conditions, including sepsis and autoimmune diseases. Elevated levels of cfDNA are found in patients with conditions like rheumatoid arthritis and systemic lupus erythematosus (SLE), potentially guiding diagnosis and treatment strategies.

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iCATCHER - Next Generation Extractor

Design to capture cfDNA, cfRNA from up to 4 ml plasma and elute into only 30 ul eluate.

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Analyze cfDNA by Qsep 

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Circulating cell-free DNA (cfDNA) in liquid biopsies is a promising source of biomarkers. Therefore, how to capture higher yield and higher purity of cfDNA is the first step and very important step of cancer early detection and cancer monitoring.
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Comparison

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The cfDNA intensity purified by iCATCHER is 4 times than magnetic bead system !!!

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Who are using iCATCHER

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HOW iCATCHER

Large Volume

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Up to 4 ml sample input !
Down to 30µl eluate output!
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Membrane Based

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Like fishing net, we utilize membrane to capture more rare nucleic acid!
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Wash Away

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Like showering, buffers pass through membrane to wash away impurities! ​
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More than cfDNA

iCATCHER was born for large volume Liquid Biopsy. However, because unique membrane column based design and wash away washing method. It's also excellent in many difficult targets of nucleic acid.  
cfRNA
​& miRNA
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FFPE
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DNA / RNA
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Stool
​DNA
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4 ml Whole Blood gDNA
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VISION

We believe,
​Cancer will become kind of Chronic Disease.
​If we can detect it in early stage and monitor it.
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ABOUT

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iCATCHER System
WHY iCATCHER
HOW iCATCHER
​WHAT iCATCHER

iCATCHER Kits

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CONTACT

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​© COPYRIGHT 2023-2024. ALL RIGHTS RESERVED.
  • About Us
  • Products
    • iCATCHER System
    • iCATCHER Kits >
      • Auto DNA
      • Auto RNA
      • Auto TNA
      • Auto CNA
    • CatchGene Manual Kit >
      • Manual DNA
      • Manual RNA
      • Manual TNA
      • Manual CNA
      • Exosome
  • News
  • User Stories
    • ACT Genomics
    • BIOTOOLS
    • Genomics
  • Contact Us